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Research Highlight

Inoue and Zhang,
Science 2011
Replication-dependent loss of 5hmC in mouse preimplantation embryos

Photo Credit: Azusa Inoue
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Research Interests


A blastocyst embryo stained with Oct4 and Cdx2 antibodies



Photo Credit: Azusa Inoue
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Research Interests


A primary human islet stained with Insulin, Glucagon and PDX1 antibodies


Photo Credit: Wei Jiang
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Research Interests


Mouse embryos at different developmental stages



Credit: Inoue and Yamaguchi
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Research Interests


In vitro cultured cortical neurons




Photo Credit: Tao and Wu
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Research Interests


Staining of a mitotic MII oocyte with tubulin, H4K20me3, and CREST antibodies


Photo Credit: Azusa Inoue
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Figure of the Month

Yamaguchi et al.,
Nature 2012
Tet1 controls meiosis by regulating meiotic gene expression

"Univalent chromosomes in Tet1-deficient female germ cells"
Photo Credit: Shinpei Yamaguchi
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  Announcements   Recent Publications   Recent News  
  »    Congratulations to Diana Cai, receiving the NSF Graduate Research Fellowship
Apr 15, 2013    

»    Big welcome to Drs. Xiang Ma, Wen Yuan, and Yuting Liu!
Jan 17, 2013    

»    Big welcome to Diana Cai and Gustavo German, two new students, joining our lab!
Dec 22, 2012    

»    Congratulations to Shinpei Yamaguchi and Shogo Matoba, both receiving JSPS Postdoctoral Fellowship for Research Abroad
Oct 9, 2012    

»    Student, postdoc and
technician positions are
available for the studies of
epigenetic regulation in
development, stem cell,
reward-related learning and memory »
Jul 4, 2012    

  » Jiang, W., Zhang, D., Bursac, N., Zhang, Y. (2013) WNT3 is a biomarker capable of predicting definitive endoderm differentiation potential of hESCs.
Stem Cell Reports. In press. »

» Lin, F., Shen, L., Jang, C., Falnes, P., and Zhang, Y. (2013) Ikbkap/Elp1 deficiency causes male infertility by disrupting meiotic progression.
PLOS Genetics. In press. »

» Shen, L., Wu, H., Diep, D., Yamaguchi, S., D'Alessio, A., Fung, H., Zhang, K., and Zhang, Y. (2013). Genome-wide analysis reveals TET- and TDG-dependent 5-methylcytosine oxidation dynamics.
Cell. In press. »

»Shen, L., Zhang, Y. (2013). 5-Hydroxymethylcytosine: generation, fate, and genomic distribution.
Curr. Opin. Cell Biol. In press. »

» He, J., Shen, L., Wan, M., Taranova, O., Wu, H., and Zhang, Y. (2013). Kdm2b maintains murine embryonic stem cell status by recruiting PRC1 complex to CpG islands of developmental genes.
Nat Cell Biol. In press. »

  »Zhang labs received funds to study epigenetic mechanism of brain reward and drug addiction »
Oct, 2012    

» UNC researchers identify important step in sperm reprogramming »
Sep, 2011    

» UNC researchers identify 7th and 8th bases of DNA »
Jul, 2011    

» Tet further revealed! Studies track protein relevant to stem cells, cancer »
Mar, 2011    

 
 
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