The Wong Lab

Single-molecule Force Studies


Our group studies how biological systems work at the nanoscale, and the physical laws that govern their behavior. We are particularly interested in the weak, non-covalent interactions between and within biological molecules (e.g. base-pairing in nucleic acids, receptor-ligand bonding, protein folding, etc.), and the coupling of these interactions to mechanical force. To investigate these issues, we develop and apply novel techniques in single-molecule manipulation, detection, and analysis, including optical tweezers methods and high-resolution optical detection.

Please take a look around our website to learn more. Read more about our research, learn about our members, peruse our publications, find out about new happenings in our group, or click here to contact us.

Our group is part of the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School, and the Immune Disease Institute at Children’s Hospital Boston, and is affiliated with the Wyss Institute for Biologically Inspired Engineering at Harvard University. And come back soon, as we are currently adding to and improving our new website.

Welcome to the Wesley P. Wong Lab at Harvard

Our group develops and applies new techniques in single-molecule manipulation to study biological systems at the nanoscale.

We have published a paper in Science Magazine on VWF and the molecular basis for the regulation of blood clotting.News/Entries/2009/6/5_new_publication__vwf_and_the_regulation_of_blood_clotting.html
Our first paper on single-molecule centrifugation has just been published!News/Entries/2010/6/2_New_publication__single-molecule_centrifugation.html
“Physical manipulation of the E.coli chromosome reveals its soft nature” now in PNAS.Publications.html
Just published: we’ve developed a single-molecule mechanical switch using DNA self-assembly.Research/Entries/2012/2/7_Nanoengineering_functional_single-molecule_tools_with_DNA_self-assembly.html