Lymph-node microcirculation: This movie shows the location of B (green) and T cells (red) in the lymph node, relative to the microcirculation (which has been visualized by injection of a mixture of red and green fluorescent dextrans, and appears yellow). B cells are located in the distal B-cell follicles, whereas T cells remain in the paracortex.
Lymph conduits. Injection of fluorescent dextran (green) into the skin allows visualization of the afferent lymph vessel in a mouse popliteal lymph node. The lymph fluid accumulates below the lymph-node capsule (blue).
Exlusion of large molecules from the lymph-node parenchyma. This movie shows that the fluorescent lymph remains confined to the subcapsular sinus and does not penetrate the lymph node parenchyma.
von Andrian, U.H. and Mempel, T. Homing and Cellular Traffic in Lymph Nodes. Nature Reviews Immunology 3: 867-878, 2003. [Abstract] [Full Text PDF]
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