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Timothy A. Springer |
Springer Career Narrative |
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Latham Family Professor of Pathology
Department of Pathology, Harvard Medical School
Immune Disease Institute
Immune Disease Institute
3 Blackfan Circle
3rd Floor, Room 3103
Boston, MA 02115
Phone: (617) 713-8200
Fax: (617) 713-8232
e-mail: springer@idi.harvard.edu |
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Major Research Interests:
Adhesion Receptors of the Immune System |
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Education:
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| 1971 |
B.A. |
University of California, Berkeley (Biochemistry) |
| 1976 |
Ph.D. |
Harvard University (Biochemistry and Molecular Biology) |
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Postdoctoral Training: |
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| 1976-1977 |
National Institutes of Health Research Fellow, University of Cambridge,England, and MRC Laboratory of Molecular Biology, Cambridge, England (César Milstein)
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Academic Appointments:
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| 1977-1983 |
Assistant Professor |
Harvard Medical School |
| 1983-1989 |
Associate Professor |
Harvard Medical School |
| 1981-1988 |
Chief |
Laboratory of Membrane Immunochemistry, Dana Farber Cancer Institute |
| 1988-1992 |
Vice President |
Center for Blood Research |
| 1989- |
Latham Family Professor of Pathology |
Harvard Medical School |
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Awards and Honors: |
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| 1966 |
National Merit Scholar |
| 1971 |
Phi Beta Kappa |
| 1971 |
Biochemistry Departmental Citation (awarded to most outstanding graduate) |
| 1971 |
B.A. with Distinction in General Scholarship and Great Distinction in the Major |
| 1981 |
American Cancer Society Junior Faculty Research Award |
| 1984 |
American Cancer Society Faculty Research Award |
| 1988 |
MERIT Grant Award, National Institutes of Health |
| 1989- |
Councilor, International Leukocyte Workshop |
| 1992 |
Distinguished Lectureship, Vanderbilt School of Medicine |
| 1993 |
American Heart Association Basic Research Prize |
| 1994 |
Royal Society of Medicine, Medal, Visiting Professor, United Kingdom |
| 1995 |
William B. Coley Medal for Distinguished Research in Fundamental Immunology, Cancer Research Institute |
| 1995 |
Marie T. Bonazinga Award for Excellence in Leukocyte Biology Research, Society for Leukocyte Biology |
| 1996- |
Member, National Academy of Sciences |
| 1997 |
Wellcome Visiting Professor, Wayne State University |
| 2001- |
Fellow, American Academy of Arts and Sciences |
| 2004 |
MERIT Grant Award, National Institutes of Health |
| 2004 |
Crafoord Prize in Polyarthritis, Royal Swedish Academy of Sciences |
| 2004 |
Fellowship, John Simon Guggenheim Memorial Foundation |
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Major Committee Assignments:
National and Regional: |
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| 1980 |
Panel Member, NIAID Study Group on Immunology |
| 1982 |
Ad Hoc Member, Experimental Immunology Study Section |
| 1985 |
Ad Hoc Member, Allergy and Immunology Study Section |
| 1986 |
Ad Hoc Member, Board of Scientific Councilors, National Institutes of Allergy and Infectious Disease |
| 1986-1990 |
Member, Allergy and Immunology Study Section, National Institutes of Health |
| 1989- |
Councilor, International Leukocyte Workshop |
| 1990 |
Organizer, International Conference on Leukocyte Adhesion Molecules, Titisee, Germany |
| 1990-1992 |
Executive Committee, International Congresses on Inflammation |
| 1991 |
Organizer, Banbury Center Conference on Adhesion Molecule Receptors and Disease, Cold Spring Harbor, New York |
| 1991 |
Organizer, Juan March Foundation Workshop on Adhesion Receptors in the Immune System, Madrid, Spain |
| 1991-1993 |
Scientific Advisory Board, New England Regional Primate Research Center |
| 1994 |
Co-Organizer, Keystone Symposium on "Biology of Physicochemical Interactions at the Cell Surface" |
| 1992-1994 |
Chair, Adhesion Structures Section, Fifth International Leukocyte Workshop |
| 1994-1996 |
Chair, Endothelial Cell Section, Sixth International Leukocyte Workshop |
| 1996-2000 |
Howard Hughes Medical Institute, Scientific Review Board |
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Harvard: |
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| 1982-1994 |
Committee on Cell and Developmental Biology |
| 1989- |
Executive Committee, Committee on Immunology |
| 1989-1991 |
Ryan Fellowship Committee |
| 1989-1992 |
Center for Blood Research, Planning Director for Space in the Warren Alpert Building |
| 1990-1993 |
Member and then Chair, Dunham Lectureship Committee |
| 1991-1993 |
Faculty Fellowships Committee |
| 1991- |
Chair and member, numerous ad hoc search committees for full professors and junior faculty members |
| 1991-1994 |
Committee on Immunology, Admissions Committee |
| 1989- |
Appointments Committee, Center for Blood Research |
| 1993-1994 |
Health Sciences and Technology Fellowships Committee |
| 1993- |
Executive Committee, Department of Pathology |
| 1994- |
Ph.D. Program Faculty in Biomedical and Biological Sciences |
| 1996- |
Member, Faculty Council |
| 2002- |
Overseer, Board of Overseers, The CBR Institute for Biomedical Research, Inc. |
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Editorial Boards:
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| 1981-1985 |
Associate Editor, Journal of Immunology |
| 1981- |
Editorial Board, Hybridoma |
| 1985-1995 |
Advisory Editor, Journal of Experimental Medicine |
| 1988- |
Editorial Board, Regional Immunology |
| 1988-1993 |
Editorial Board, Cellular Immunology |
| 1988-1992 |
Editorial Board, Journal of Clinical Immunology |
| 1989-1992 |
Editorial Board, New Biologist |
| 1989-1992 |
Editorial Board, Cell Regulation (Molecular Biology of the Cell) |
| 1992-1996 |
Associate Editor, Molecular Biology of the Cell |
| 1996-2001 |
Editorial Board, Immunological Reviews |
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Memberships and Committee Assignments in Professional Societies: |
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| 1979- |
American Association of Immunologists |
| 1981-1994 |
Reticuloendothelial Society |
| 1982- |
American Society of Biological Chemists |
| 1985-1986 |
American Association of Immunologists Meeting, Block Chairman, Macrophages & Natural Killer Cells |
| 1986 |
Reticuloendothelial Society, Membership Chair |
| 1987 |
Program Committee, Reticuloendothelial Society (chair 1989) |
| 1989- |
American Association of Pathologists |
| 1993 |
Nomination Committee, American Association of Immunologists |
| 1995- |
Society for Leukocyte Biology |
| 1996- |
National Academy of Sciences |
| 2001 |
Canadian Vaccines and Immunotherapeutics Network, Scientific Advisor |
| 2004-2007 |
Chair of Section 29, Biophysics and Computational Biology, National Academy of Sciences |
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Consulting: |
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| 1989-1995 |
Boehringer-Ingelheim
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| 1992-1999 |
LeukoSite, Inc., Founder and Chairman of Scientific Advisory Board
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| 1997- |
Molecular Applications Group, Inc., Scientific Advisory Board
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| 1999-2001 |
Millennium Pharmaceuticals |
| 2003- |
Sunesis Pharmaceuticals |
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Teaching Experience:
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| 1972-1974 |
Harvard University, Biochemistry 10 Teaching Assistant |
| 1974-1975 |
Harvard University, Biochemistry 111 Teaching Assistant |
| 1981 |
Instructor, Alton Jones Cell Culture Center Course on Macrophages, Lake Placid, NY |
| 1984, 1986 |
Developed and led Harvard Medical School Continuing Education Course, "Hybridomas in Biotechnology and Medicine" |
| 1985- |
Course leader and lecturer, Harvard University, Immunology 203, "Biochemistry and Molecular Biology of the Immune System" |
| 1988- |
Lecturer, "Identity, Microbes and Defense," in New Pathway Curriculum |
| 1989 |
Lecturer, Human Pathology, HST-030
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| 1988- |
Lecturer, Cell Biology 200a "Molecular Development of the Cell"
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| 1993 |
Lecturer, Human Pathology, HST-030
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| 1994 |
Course leader and lecturer, Harvard University, Immunology 203,
"Biochemistry and Molecular Biology of the Immune System" |
| 1994 |
Lecturer, Human Pathology, HST-030
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| 1995 |
Lecturer, Human Pathology, HST-030
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| 1995 |
Lecturer, Harvard Medical School Immunology Seminar
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| 1995 |
Lecturer, Harvard University Department of Molecular and Cellular Biology Seminar Series |
| 1996 |
Lecturer, Human Pathology, HST-030
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| 1996 |
Lecturer, Harvard Medical School Immunology Seminar
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| 1997 |
Lecturer, Harvard Medical School Pathology Seminar
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| 1997 |
Lecturer, Human Pathology, HST-030
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| 1998 |
Lecturer, Human Pathology, HST-030
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| 1998 |
Lecturer, Harvard University, Advanced Biomedical Sciences Course "Revisiting Biomedical Sciences and Pathology"
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| 1999 |
Lecturer, Harvard University, Molecular and Cellular Immunology 169 |
| 1999 |
Presentation to Graduate Students, Harvard University, Biological and Biomedical Sciences |
| 1999, 2001 |
Lecturer, Harvard University, Molecular Immunology 268 |
| 2003 |
Lecturer, Harvard University, Immunology Critical Reading Course 204 |
| 2007 |
Lecturer, Harvard University, Department of Biological Chemistry and Molecular Pharmacology 201 Proteins |
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Selected Lectures and Honors:
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| 1990 |
Visiting Professor, University of Michigan
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| 1991 |
Centennial Celebration-Scientific Symposium, Washington University School of Medicine |
| 1991 |
Harvey Lecturer, William Harvey Research Institute, St. Bartholomew's, London, England |
| 1992 |
Keynote Address, joint Keystone Symposia on "Inflammation, Growth Regulatory Molecules, and Atherosclerosis", and "The Molecular Biology of the Endothelial Cell" |
| 1992 |
Ninth Zoltan Ovari Symposium Lecturer, The Honors Program, New York University Medical Center |
| 1992 |
First Annual Invited Speaker, Pathology Department, Albert Einstein School of Medicine |
| 1992 |
14th Annual Jim McGinnis Memorial Lecturer, Duke University Medical Center |
| 1992 |
Lecturer, National Heart, Lung and Blood Institute Symposium on Atherosclerosis to Honor Gardner McMillian, Bethesda, Maryland |
| 1992 |
Boehringer-Ingelheim Distinguished Lecturer in Biomedical Sciences, Vanderbilt University |
| 1993 |
Lecturer, William B. Coley Symposium, Frontiers of Immunology and Cancer Immunology, Cancer Research Institute and Memorial Sloan-Kettering, New York, New York |
| 1994 |
Lecturer, The Harvey Society, New York, New York |
| 1994 |
Juan March Foundation Lecturer, Madrid, Spain |
| 1994 |
Basic Science Lecturer, The American Association for Thoracic Surgery Annual Meeting, New York, New York |
| 1994 |
Burroughs-Wellcome Visiting Professor, Royal Society of Medicine, London, Cambridge, Birmingham, and Oxford, England |
| 1994 |
Second Annual Norman Heatley Lecturer, University of Oxford, Sir William Dunn School of Pathology, Oxford, England |
| 1995 |
Second Daiichi Lecturer, University of California, San Francisco, "The effect of force on bond lifetimes :Are selectins and integrins specialized for high tensile strength?" |
| 1995 |
Lecturer, Nobel Conference on "Cell Adhesion Molecules and Cell-Matrix Receptors in Vertebrate Tissues", Karolinska Institutet, Stockholm, Sweden |
| 1995 |
Plenary Speaker and Symposium Co-Chair on Selectins, World Congress on Inflammation, Brighton, England |
| 1996 |
Plenary Lecturer, Keystone Symposium, Exploring and Exploiting Antibody and Ig Superfamily Combining Sites, Taos, New Mexico |
| 1996 |
Co-Organizer and Speaker, Vascular Endothelium and Regulation of Leukocyte Traffic Meeting, Instituto Juan March de Estudios e Investigaciones, Madrid, Spain |
| 1997 |
Wellcome Visiting Professor, Wayne State University, Detroit, Michigan |
| 1998 |
Presidential Symposium Speaker on Integrin Receptors, American Society of Haematology, Miami, Florida. |
| 1998 |
Keynote Lecturer, Third International Workshop on Signal Transduction in the Activation and Development of Mast Cells and Basophils, The National Institute of Health, Bethesda, Maryland. |
| 1999 |
John T. Edsall Lecturer, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts |
- 2000
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George W. Raiziss Biochemical Rounds Seminar Series, "Molecular Interactions in Biology and Medicine", University of Pennsylvania School of Medicine, Philadelphia |
| 2001 |
Keynote Address, Keystone Symposium, “Chemokine and Chemokine Receptors”, Taos, New Mexico |
| 2001 |
Keynote Speaker, NCI Center for Cancer Research, Fellows Symposium, Bethesda, Maryland |
| 2003 |
Speaker, The Future of Structural Biology, New York Structural Biology Center, New York, New York |
| 2003 |
Speaker, Dean's Lecture at Mount Sinai School of Medicine, New York, New York |
| 2004 |
Speaker, President's Research Seminar Series, Memorial Sloan-Kettering Cancer Center, New York, New York |
| 2006 |
12th Annual Edmond Alexandre Goidl Lectureship, on Immunology University of Maryland at Baltimore, School of Medicine, Baltimore, Maryland |
| 2008 |
Keynote Speaker, "Transendothelial Migration and Bidirectional Signal Transmission in Integrins", Keystone Symposia, Keystone, CO |
| 2008 |
Keynote Speaker, Bernie B. Carter Annual Lecture, University of Virginia Health System at University of Virginia, Charlottesville, VA |
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