Integrin seven-bladed beta-propeller domain
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High affinity integrin I-domain
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ICAM-1 D1-D2 crystal structure
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LDL receptor six-bladed beta-propeller domain
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PDB Query of Springer Lab Structures

Integrin beta-propeller domain

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• PDB entry 1A8X: Download
• Publications:
  1. Springer, T.A., (1997) Folding of the N-terminal, ligand-binding region of integrin alpha-subunit into a beta-propeller domain. Proc. Natl. Acad. Sci. USA, 94:65-72.
  2. Oxvig, C. and Springer, T.A. (1998) Experimental support for a beta-propeller domain in integrin alpha-subunit and a calcium binding site on its lower surface. Proc. Natl. Acad. Sci. USA, 95:4870-4875.

Integrin I-domain

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• PDB entry 1IDO (related) :Download
• Publications:
  Shimaoka, M., Shifman, J.M., Jing, H., Takagi, J., Mayo, S.L., Springer, T.A. (2000) Computational design of an integrin I domain stabilized in the open, high affinity conformation. Nat. Struct. Biol., 7: 674-678.

ICAM-1 D1-D2 domains

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• PDB entry 1IC1: Download
• Publications:
  Casasnovas, J.M., Stehle, T., Liu, J.H., Wang, J.H., Springer, T.A. (1998) A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1. Proc. Natl. Acad. Sci. USA, 95:4134-4139.
  

ICAM-2

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• PDB entry 1ZXQ: Download
• Publications:
  Casasnovas, J.M., Springer, T.A., Liu, J.H., Harrison, S.C., Wang, J.H. (1997) Crystal structure of ICAM-2 reveals a distinctive integrin recognition surface. Nature, 387:312-315.

MAdCAM-1

• Images
• PDB entry 1BQS: Download
• Publications:
  Tan, K., Casasnovas, J.M., Liu, J.H., Briskin, M.J., Springer, T.A., Wang, J.H. (1998) The structure of immunoglobulin superfamily domains 1 and 2 of MAdCAM-1 reveals novel features important for integrin recognition. Structure, 15:793-801.

YWTD Repeats

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• PDB entry 1NDX (nidogen): Download
  PDB entry 1LRX (LDL receptor): Download
  PDB entry 1LPX (LDL receptor-related protein 1): Download
• Publications:
  Springer, T.A. (1998) An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components. J. Mol. Biol., 283:837-862.