Timothy A. Springer

 

 

Latham Family Professor


Professor of Biological Chemistry and Molecular Pharmacology
Professor of Medicine
Harvard Medical School

 

Program in Cellular and Molecular Medicine
Division of Hematology
Department of Medicine
Boston Children's Hospital

3 Blackfan Circle, Room 3103
Boston, MA 02115

Phone: (617) 713-8200
Fax: (617) 713-8232

e-mail: timothy.springer at childrens.harvard.edu



 Springer Career Narrative

 

Major Research Interests:

Adhesion Receptors of the Immune System
 

Education:

  1971 B.A.  University of California, Berkeley (Biochemistry)
  1976 Ph.D Harvard University (Biochemistry and Molecular Biology)
 

Postdoctoral Training:

  1976-1977 National Institutes of Health Research Fellow, University of Cambridge,England, and MRC Laboratory of Molecular Biology, Cambridge, England (César Milstein)
 

Academic Appointments:

  1977-1983 Assistant Professor, Harvard Medical School
  1983-1989 Associate Professor, Harvard Medical School
  1981-1988 Chief, Laboratory of Membrane Immunochemistry, Dana Farber Cancer Institute
  1988- Senior Investigator, Immune Disease Institute (formerlly Center for Blood Research)
  1988-1992 Vice President, Immune Disease Institute (formerlly Center for Blood Research)
  1989- Latham Family Professor, Harvard Medical School
  1989-2011 Professor of Pathology, Harvard Medical School
  2004- Honorary Chair Professor, Fudan University, Shanghai, China
  2006- Honorary Professor, College of Life Sciences, Nankai University, Tianjin, China
  2007- Honorary Professor, Shanghai Jiao Tong University, Shanghai, China
  2011- Professor of Biological Chemistry and Molecular Pharmacology, Harvard Medical School
  2011- Professor of Medicine, Boston Children's Hospital
 

Awards and Honors:

  1966 National Merit Scholar
  1971 Phi Beta Kappa
  1971 Biochemistry Departmental Citation (awarded to most outstanding graduate)
  1971 B.A. with Distinction in General Scholarship and Great Distinction in the Major
  1981 American Cancer Society Junior Faculty Research Award
  1984-1989 American Cancer Society Faculty Research Award
  1988 MERIT Grant Award, National Institutes of Health
  1989-1998 Councilor, International Leukocyte Workshop
  1992 Distinguished Lectureship, Vanderbilt School of Medicine
  1993 American Heart Association Basic Research Prize
  1994 Royal Society of Medicine, Medal, Visiting Professor, United Kingdom
  1995 William B. Coley Medal for Distinguished Research in Fundamental Immunology, Cancer Research Institute
  1995 Marie T. Bonazinga Award for Excellence in Leukocyte Biology Research, Society for Leukocyte Biology
  1996- Member, National Academy of Sciences
  1997 Wellcome Visiting Professor, Wayne State University
  2001- Fellow, American Academy of Arts and Sciences
  2004 MERIT Grant Award, National Institutes of Health
  2004 Crafoord Prize in Polyarthritis, Royal Swedish Academy of Sciences
  2004 Fellowship, John Simon Guggenheim Memorial Foundation
  2011 Doctor Medicinae Honoris Causa, Aarhus University, Denmark
  2013- Fellow, American Association for the Advancement of Science
  2014 AAI-Life Technologies Meritorious Career Award, American Association of Immunologists
  2014 Henry M. Stratton Medal, American Society of Hematology
 

Major Committee Assignments:

National and Regional:

  1980 Panel Member, NIAID Study Group on Immunology
  1982 Ad Hoc Member, Experimental Immunology Study Section
  1985 Ad Hoc Member, Allergy and Immunology Study Section
  1986 Ad Hoc Member, Board of Scientific Councilors, National Institutes of Allergy and Infectious Disease
  1986-1990 Member, Allergy and Immunology Study Section, National Institutes of Health
  1989- Councilor, International Leukocyte Workshop
  1990 Organizer, International Conference on Leukocyte Adhesion Molecules, Titisee, Germany
  1990-1992 Executive Committee, International Congresses on Inflammation
  1991 Organizer, Banbury Center Conference on Adhesion Molecule Receptors and Disease, Cold Spring Harbor, New York
  1991 Organizer, Juan March Foundation Workshop on Adhesion Receptors in the Immune System, Madrid, Spain
  1991-1993 Scientific Advisory Board, New England Regional Primate Research Center
  1994 Co-Organizer, Keystone Symposium on "Biology of Physicochemical Interactions at the Cell Surface"
  1992-1994 Chair, Adhesion Structures Section, Fifth International Leukocyte Workshop
  1994-1996 Chair, Endothelial Cell Section, Sixth International Leukocyte Workshop
  1996-2000 Howard Hughes Medical Institute, Scientific Review Board
  2010- Board of Trustees, Boston Children's Hospital Boston Trust

Harvard:

  1982-1994 Committee on Cell and Developmental Biology
  1989- Executive Committee, Committee on Immunology
  1989-1991 Ryan Fellowship Committee
  1989-1992 Center for Blood Research, Planning Director for Space in the Warren Alpert Building
  1990-1993 Member and then Chair, Dunham Lectureship Committee
  1991-1993 Faculty Fellowships Committee
  1991- Chair and member, numerous ad hoc search committees for full professors and junior faculty members. Recruits from committees chaired: Rick van Etten, Jose-Carlos Gutierrez-Ramos, Uli von Andrian, Anjana Rao, Denisa Wagner, Sun Hur, Wesley Wong
  1991-1994 Committee on Immunology, Admissions Committee
  1989- Appointments Committee, Center for Blood Research
  1993-1994 Health Sciences and Technology Fellowships Committee
  1993- Executive Committee, Department of Pathology
  1994- Ph.D. Program Faculty in Biomedical and Biological Sciences
  1996- Member, Faculty Council
  2002- Overseer, Board of Overseers, The CBR Institute for Biomedical Research, Inc.
 

Editorial Boards:

  1981-1985 Associate Editor, Journal of Immunology
  1981- Editorial Board, Hybridoma
  1985-1995 Advisory Editor, Journal of Experimental Medicine
  1988- Editorial Board, Regional Immunology
  1988-1993 Editorial Board, Cellular Immunology
  1988-1992 Editorial Board, Journal of Clinical Immunology
  1989-1992 Editorial Board, New Biologist
  1989-1992 Editorial Board, Cell Regulation (Molecular Biology of the Cell)
  1992-1996 Associate Editor, Molecular Biology of the Cell
  1996-2001 Editorial Board, Immunological Reviews
 

Memberships and Committee Assignments in Professional Societies:

  1979- American Association of Immunologists
  1981-1994 Reticuloendothelial Society
  1982- American Society of Biological Chemists
  1985-1986 American Association of Immunologists Meeting, Block Chairman, Macrophages & Natural Killer Cells
  1986 Reticuloendothelial Society, Membership Chair
  1987 Program Committee, Reticuloendothelial Society (chair 1989)
  1989- American Association of Pathologists
  1993 Nomination Committee, American Association of Immunologists
  1995- Society for Leukocyte Biology
  1996- National Academy of Sciences
  2001 Canadian Vaccines and Immunotherapeutics Network, Scientific Advisor
  2004-2007 Chair of Section 29, Biophysics and Computational Biology, National Academy of Sciences
 

Consulting:

  1989-1995 Boehringer-Ingelheim
  1992-1999 LeukoSite, Inc., Founder and Chairman of Scientific Advisory Board
  1997- Molecular Applications Group, Inc., Scientific Advisory Board
  1999-2001 Millennium Pharmaceuticals
  2003- Sunesis Pharmaceuticals
 

Teaching Experience:

  1972-1974 Harvard University, Biochemistry 10 Teaching Assistant
  1974-1975 Harvard University, Biochemistry 111 Teaching Assistant
  1981 Instructor, Alton Jones Cell Culture Center Course on Macrophages, Lake Placid, NY
  1984, 1986 Developed and led Harvard Medical School Continuing Education Course, "Hybridomas in Biotechnology and Medicine"
  1985- Course leader and lecturer, Harvard University, Immunology 203, "Biochemistry and Molecular Biology of the Immune System"
  1988- Lecturer, "Identity, Microbes and Defense," in New Pathway Curriculum
  1989 Lecturer, Human Pathology, HST-030
  1988- Lecturer, Cell Biology 200a "Molecular Development of the Cell"
  1993 Lecturer, Human Pathology, HST-030
  1994 Course leader and lecturer, Harvard University, Immunology 203,
"Biochemistry and Molecular Biology of the Immune System"
  1994 Lecturer, Human Pathology, HST-030
  1995 Lecturer, Human Pathology, HST-030
  1995 Lecturer, Harvard Medical School Immunology Seminar
  1995 Lecturer, Harvard University Department of Molecular and Cellular Biology Seminar Series
  1996 Lecturer, Human Pathology, HST-030
  1996 Lecturer, Harvard Medical School Immunology Seminar
  1997 Lecturer, Harvard Medical School Pathology Seminar
  1997 Lecturer, Human Pathology, HST-030
  1998 Lecturer, Human Pathology, HST-030
  1998 Lecturer, Harvard University, Advanced Biomedical Sciences Course "Revisiting Biomedical Sciences and Pathology" 
  1999 Lecturer, Harvard University, Molecular and Cellular Immunology 169
  1999 Presentation to Graduate Students, Harvard University, Biological and Biomedical Sciences
  1999, 2001 Lecturer, Harvard University, Molecular Immunology 268
  2003 Lecturer, Harvard University, Immunology Critical Reading Course 204
  2007-2010 Lecturer, Harvard University, Department of Biological Chemistry and Molecular Pharmacology 201 Proteins

Selected Lectures and Honors:

  1990 Visiting Professor, University of Michigan
  1991 Centennial Celebration-Scientific Symposium, Washington University School of Medicine
  1991 Harvey Lecturer, William Harvey Research Institute, St. Bartholomew's, London, England
  1992 Keynote Address, joint Keystone Symposia on "Inflammation, Growth Regulatory Molecules, and Atherosclerosis", and "The Molecular Biology of the Endothelial Cell"
  1992 Ninth Zoltan Ovari Symposium Lecturer, The Honors Program, New York University Medical Center
  1992 First Annual Invited Speaker, Pathology Department, Albert Einstein School of Medicine
  1992 14th Annual Jim McGinnis Memorial Lecturer, Duke University Medical Center
  1992 Lecturer, National Heart, Lung and Blood Institute Symposium on Atherosclerosis to Honor Gardner McMillian, Bethesda, Maryland
  1992 Boehringer-Ingelheim Distinguished Lecturer in Biomedical Sciences, Vanderbilt University
  1993 Lecturer, William B. Coley Symposium, Frontiers of Immunology and Cancer Immunology, Cancer Research Institute and Memorial Sloan-Kettering, New York, New York
  1994 Lecturer, The Harvey Society, New York, New York
  1994 Juan March Foundation Lecturer, Madrid, Spain
  1994 Basic Science Lecturer, The American Association for Thoracic Surgery Annual Meeting, New York, New York
  1994 Burroughs-Wellcome Visiting Professor, Royal Society of Medicine, London, Cambridge, Birmingham, and Oxford, England
  1994 Second Annual Norman Heatley Lecturer, University of Oxford, Sir William Dunn School of Pathology, Oxford, England
  1995 Second Daiichi Lecturer, University of California, San Francisco, "The effect of force on bond lifetimes :Are selectins and integrins specialized for high tensile strength?"
  1995 Lecturer, Nobel Conference on "Cell Adhesion Molecules and Cell-Matrix Receptors in Vertebrate Tissues", Karolinska Institutet, Stockholm, Sweden
  1995 Plenary Speaker and Symposium Co-Chair on Selectins, World Congress on Inflammation, Brighton, England
  1996 Plenary Lecturer, Keystone Symposium, Exploring and Exploiting Antibody and Ig Superfamily Combining Sites, Taos, New Mexico
  1996 Co-Organizer and Speaker, Vascular Endothelium and Regulation of Leukocyte Traffic Meeting, Instituto Juan March de Estudios e Investigaciones, Madrid, Spain
  1997 Wellcome Visiting Professor, Wayne State University, Detroit, Michigan
  1998 Presidential Symposium Speaker on Integrin Receptors, American Society of Haematology, Miami, Florida.
  1998 Keynote Lecturer, Third International Workshop on Signal Transduction in the Activation and Development of Mast Cells and Basophils, The National Institute of Health, Bethesda, Maryland.
  1999 John T. Edsall Lecturer, Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts
 
2000
George W. Raiziss Biochemical Rounds Seminar Series, "Molecular Interactions in Biology and Medicine", University of Pennsylvania School of Medicine, Philadelphia
  2001 Keynote Address, Keystone Symposium, “Chemokine and Chemokine Receptors”, Taos, New Mexico
  2001 Keynote Speaker, NCI Center for Cancer Research, Fellows Symposium, Bethesda, Maryland
  2003 Speaker, The Future of Structural Biology, New York Structural Biology Center, New York, New York
  2003

Speaker, Dean's Lecture at Mount Sinai School of Medicine, New York, New York

  2004 Speaker, President's Research Seminar Series, Memorial Sloan-Kettering Cancer Center, New York, New York
  2006 12th Annual Edmond Alexandre Goidl Lectureship, on Immunology University of Maryland at Baltimore, School of Medicine, Baltimore, Maryland
  2008 Keynote Speaker, "Transendothelial Migration and Bidirectional Signal Transmission in Integrins", Keystone Symposia, Keystone, CO
  2008

Keynote Speaker, Bernie B. Carter Annual Lecture, University of Virginia Health System at University of Virginia, Charlottesville, VA

  2009 Keynote Speaker, “Bidirectional Signaling through Integrins Reinforces Ligand and Cytoskeleton Engagement”, Montana State University, Bozeman, MT
  2009 Keynote Speaker, “Interactions Between Platelets, von Willebrand Factor, and Hydrodynamic Shear Force", Eighth Annual Aster Lecture, BloodCenter of Wisconsin, Blood Research Institut, Milwaukee, WI
  2009 Physiology Course Lecturer, Woods Hole Marine Biological Laboratory
  2009 Speaker, "The Shear-Sensor Domain in the Ultra-Large Protein - von Willebrand Factor", PhysCell 2009, Primosten, Croatia
  2009 Lecturer, Tri-Institutional Structural Biology Seminar Series, Memorial Sloan-Kettering Cancer Center and Weill Medical College, Rockefeller University, New York, NY
  2009 Roon Visiting Lecturer, “Interactions Between Platelets, von Willebrand Factor, and Hydrodynamic Shear Force”, The Scripps Research Institute, San Diego, CA
  2010 Speaker, Molecular Biophysics Discussion group, UT Southwestern Medical Center, Dallas, TX
  2010 Platform Speaker, "Toward the Structure of the Epidermal Growth Factor Receptor on Intact Cells", Structural Analysis of Supramolecular Assemblies by Hybrid Methods, Lake Tahoe, CA
  2010 Speaker, “The Flex-Bond, a Mechanically Stabilized Receptor-Ligand Bond Important in the Vasculature”, University of Illinois, Cell and Developmental Biology Seminar, Urbana, IL
  2010 Keynote Speaker, “The Traction Force Model for Integrin Activation”, 2010 GRC Signaling by Adhesion Receptors, Colby College, Waterville, ME
  2010 Speaker, “The Traction-Force Model for Integrin Activation”, University of Aarhus, Department of Molecular Biology, Denmark
  2011 Guest lecturer, "Traction Force Model for Integrin Activation", Immunology and Microbial Science Affinity group, The Scripps Research Institute, La Jolla, CA
  2011 Speaker, "The Evidence of the Traction Force Model of Integrin Activation", Fibronectin, Integrins and Related Molecules Gordon Research Conference, Lucca, Italy
  2011 State of the Art Lecturer, "The Domain Architecture of VWF and Activation by Elongational Flow", XXIII Congress of the International Society on Thrombosis and Haemostasis, Kyoto, Japan