Eun Jeong Park joined the Shimaoka lab in 2004, where
he has generated knock-in mice harboring aberrantly
activated integrins. His research interest is focused
on understanding the influences of the persistently
activated integrins on lymphoid organ development,
lymphocyte adhesion and migration in vivo, and the
inflammatory disease progression. His long-term goal is
to translate his findings into a novel treatment of
inflammatory disorders in patients. Dr. Park has been
selected to give a talk at
Gordon Research Conference
in 2007.
Contact:
Phone:
617-713-8392
E-mail: epark@idi.harvard.edu
Eun Jeong Park, Ph.D.
Instructor
Department Anesthesia, Harvard Medical School
Immune Disease Institute
Education:
1995 M.S. Dept. Biological Science, Sungkyunkwan Univ, Korea
2004 Ph.D. Osaka Univ Medical School, Japan
Position & Employment:
1994-1999 Res. Scientist/Senior Res. Scientist, Mogam Biotechn. Res. Institute, Korea
2001-2003 Res. Assistant, Res Inst Microb Dis, Osaka University, Japan
2003-2004 Res. Assistant, Inst Med Sci, The University of Tokyo, Japan
2003-2004 Special Res. Fellow, Inst Med Sci, The University of Tokyo, Japan
2004- Postdoctoral Fellow, CBR Institute for Biomedical Research, Harvard Medical School
2009- Instructor, Immune Disease Institute and Harvard Medical School.
Honors & Awards:
1988-1990 Military Service, Army of Republic of Korea
2003-2004 Yoneyama Rotary Scholarship
Publications:
1. Kim JH, Park EJ, Lee TK, and Lee WS. 1996. Genomic sequences of the soybean 24 kDa oleosin genes and initial analysis of their promoter sequences. Mol. Cells. 6:393-399.
2. Won J, Kim H, Park EJ, Hong Y, Kim SJ, and Yun Y. 1999. Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor-beta receptor therapy. Cancer Res. 59:1273-1277.
3. Park EJ, Chang JH, Kim JS, Chung SI, and Yum JS. 1999. Development of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin. Exp. Mol. Med. 31:101-107.
4. Park EJ, Chang JH, Kim JS, Yum JS, and Chung SI. 2000. The mucosal adjuvanticity of two nontoxic mutants of Escherichia coli heat-labile enterotoxin varies with immunization routes. Exp. Mol. Med. 32:72-78.
5. Kim JS, Chang JH, Park EJ, Chung SI, and Yum JS. 2000. Evaluation of factors that can affect protective immune responses following oral immunization of recombinant Helicobacter pylori urease apoenzyme. J. Microbiol. Biotechn. 10:865-872.
6. Takahashi I, Park EJ, and Kiyono H. 2002. Mucosal T cells and inflammatory bowel diseases. Molecular Medicine 39(9):1000-1007 (review).
7. Kinoshita N, Hiroi T, Ohta N, Fukuyama S, Park EJ, and Kiyono H. 2002. Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithel NK cells. J. Immunol. 169:6187-6192.
8. Park EJ, Takahashi I, Ikeda J, Kawahara K, Okamoto T, Kweon MN, Fukuyama S, Groh V, Spies T, Obata Y, Miyazaki JI, and Kiyono H. 2003. Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium. J. Immunol. [Journal cover] 171:4131-4139.
9. Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S, and Kiyono H. 2004. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J. Immunol. 173:3337-3347.
10. Kweon MN, Yamamoto M, Rennert PD, Park EJ, Lee AY, Chang SY, Hiroi T, Nanno M, and Kiyono H. 2005. Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. J. Immunol. 174:4365-4372.
11. Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, and Kiyono H. 2006. Cutting Edge: Uniqueness of lymphoid chemokine receptor requirement for the initiation and maturation of NALT organogenesis. J. Immunol. 177:4276-4280.
12. Park EJ, Mora JR, Carman CV, Chen JF, Sasaki Y, Cheng, G., von Andrian UH, Shimaoka M. 2007. Aberrant activation of integrin alpha4beta7 suppresses lymphocyte homing to the gut. J. Clin. Invest. 117: 2526-2538.
13. Peer, D., Park, E.J., Morishita, Y., Carman, C.V., Shimaoka, M. 2008 Systemic leukocyte-directed sirNA delivery revealing cyclin D1 as an anti-inflammatory target. Science. 2008. 319: 627-630.
13. Imai Y*, Park EJ*, Peer D, Peixoto A, Cheng G, von Andrian UH, Carman CV, Shimaoka M. Genetic perturbation of the putative cytoplsmic membrane-proximal salt bridge aberrantly activates alpha4 integrin. Blood (in press) (*equally contributed)
Instructor
Department Anesthesia, Harvard Medical School
Immune Disease Institute
Education:
1995 M.S. Dept. Biological Science, Sungkyunkwan Univ, Korea
2004 Ph.D. Osaka Univ Medical School, Japan
Position & Employment:
1994-1999 Res. Scientist/Senior Res. Scientist, Mogam Biotechn. Res. Institute, Korea
2001-2003 Res. Assistant, Res Inst Microb Dis, Osaka University, Japan
2003-2004 Res. Assistant, Inst Med Sci, The University of Tokyo, Japan
2003-2004 Special Res. Fellow, Inst Med Sci, The University of Tokyo, Japan
2004- Postdoctoral Fellow, CBR Institute for Biomedical Research, Harvard Medical School
2009- Instructor, Immune Disease Institute and Harvard Medical School.
Honors & Awards:
1988-1990 Military Service, Army of Republic of Korea
2003-2004 Yoneyama Rotary Scholarship
Publications:
1. Kim JH, Park EJ, Lee TK, and Lee WS. 1996. Genomic sequences of the soybean 24 kDa oleosin genes and initial analysis of their promoter sequences. Mol. Cells. 6:393-399.
2. Won J, Kim H, Park EJ, Hong Y, Kim SJ, and Yun Y. 1999. Tumorigenicity of mouse thymoma is suppressed by soluble type II transforming growth factor-beta receptor therapy. Cancer Res. 59:1273-1277.
3. Park EJ, Chang JH, Kim JS, Chung SI, and Yum JS. 1999. Development of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin. Exp. Mol. Med. 31:101-107.
4. Park EJ, Chang JH, Kim JS, Yum JS, and Chung SI. 2000. The mucosal adjuvanticity of two nontoxic mutants of Escherichia coli heat-labile enterotoxin varies with immunization routes. Exp. Mol. Med. 32:72-78.
5. Kim JS, Chang JH, Park EJ, Chung SI, and Yum JS. 2000. Evaluation of factors that can affect protective immune responses following oral immunization of recombinant Helicobacter pylori urease apoenzyme. J. Microbiol. Biotechn. 10:865-872.
6. Takahashi I, Park EJ, and Kiyono H. 2002. Mucosal T cells and inflammatory bowel diseases. Molecular Medicine 39(9):1000-1007 (review).
7. Kinoshita N, Hiroi T, Ohta N, Fukuyama S, Park EJ, and Kiyono H. 2002. Autocrine IL-15 mediates intestinal epithelial cell death via the activation of neighboring intraepithel NK cells. J. Immunol. 169:6187-6192.
8. Park EJ, Takahashi I, Ikeda J, Kawahara K, Okamoto T, Kweon MN, Fukuyama S, Groh V, Spies T, Obata Y, Miyazaki JI, and Kiyono H. 2003. Clonal expansion of double-positive intraepithelial lymphocytes by MHC class I-related chain A expressed in mouse small intestinal epithelium. J. Immunol. [Journal cover] 171:4131-4139.
9. Ueta M, Nochi T, Jang MH, Park EJ, Igarashi O, Hino A, Kawasaki S, Shikina T, Hiroi T, Kinoshita S, and Kiyono H. 2004. Intracellularly expressed TLR2s and TLR4s contribution to an immunosilent environment at the ocular mucosal epithelium. J. Immunol. 173:3337-3347.
10. Kweon MN, Yamamoto M, Rennert PD, Park EJ, Lee AY, Chang SY, Hiroi T, Nanno M, and Kiyono H. 2005. Prenatal blockage of lymphotoxin beta receptor and TNF receptor p55 signaling cascade resulted in the acceleration of tissue genesis for isolated lymphoid follicles in the large intestine. J. Immunol. 174:4365-4372.
11. Fukuyama S, Nagatake T, Kim DY, Takamura K, Park EJ, Kaisho T, Tanaka N, Kurono Y, and Kiyono H. 2006. Cutting Edge: Uniqueness of lymphoid chemokine receptor requirement for the initiation and maturation of NALT organogenesis. J. Immunol. 177:4276-4280.
12. Park EJ, Mora JR, Carman CV, Chen JF, Sasaki Y, Cheng, G., von Andrian UH, Shimaoka M. 2007. Aberrant activation of integrin alpha4beta7 suppresses lymphocyte homing to the gut. J. Clin. Invest. 117: 2526-2538.
13. Peer, D., Park, E.J., Morishita, Y., Carman, C.V., Shimaoka, M. 2008 Systemic leukocyte-directed sirNA delivery revealing cyclin D1 as an anti-inflammatory target. Science. 2008. 319: 627-630.
13. Imai Y*, Park EJ*, Peer D, Peixoto A, Cheng G, von Andrian UH, Carman CV, Shimaoka M. Genetic perturbation of the putative cytoplsmic membrane-proximal salt bridge aberrantly activates alpha4 integrin. Blood (in press) (*equally contributed)