Masao
Murakawa, Ph.D. joined the Shimaoka lab in 2009.
Contact:
Phone:
617-713-8385
E-mail:
murakawa@idi.harvard.edu
Masao Murakawa, Ph.D.
Postdoctoral Fellow
Department of Anesthesia, Harvard Medical School
Immune Disease Institute
Education:
1996 B.S. Kyoto University
1998 M.S. Kyoto University
2001 Ph.D. Kyoto University
2009 Postdoc Immune Disease Institute & Harvard Medical School
Position & Employment:
1998-2001 Research Fellow (DC1), The Japanese Society for the Promotion of Science (JSPS)
2001-present Asubio Pharma Co., Limited, Researcher
2008- Research Fellow, CBR Institute for Biomedical Research, Harvard Medical School
Selected publications:
1. Lee KK, Murakawa M, Nishida E, Tsubuki S, kawashima S, Sakamaki K, Yonehara S (1998). Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis. Oncogene 16, 3029-3037.
2. Lee KK, Murakawa M, Takahashi S, Tsubuki S, Kawashima S, Sakamaki K, Yonehara S (1998). Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa. J Biol Chem. 273, 19160-6.
3. Murakawa M, Jung SK, Iijima K, Yonehara S. (2001). Apoptosis-inducing protein, AIP, from parasite-infected fish induces apoptosis in mammalian cells by two different molecular mechanisms. Cell Death Differ. 8, 298-307.
4. Murakawa M, Yamaoka K, Tanaka Y, Fukuda Y. (2006). Involvement of tumor necrosis factor (TNF)-alpha in phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice. Biochem Pharmacol. 71, 1331-6
5. Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Nagahira K, Fukuda Y, Nishimura T. Murine NKT cells produce Th17 cytokine interleukin-22. (2009). Cell Immunol. 254, 81-4.
6. Kadoshima-Yamaoka K, Murakawa M, Goto M, Tanaka Y, Inoue H, Murafuji H, Hayashi Y, Nagahira K, Miura K, Nakatsuka T, Chamoto K, Fukuda Y, Nishimura T. (2009). Effect of phosphodiesterase 7 inhibitor ASB16165 on development and function of cytotoxic T lymphocyte. Int Immunopharmacol. 9, 97-102.
7. Kadoshima-Yamaoka K, Murakawa M, Goto M, Tanaka Y, Inoue H, Murafuji H, Nagahira A, Hayashi Y, Nagahira K, Miura K, Nakatsuka T, Chamoto K, Fukuda Y, Nishimura T. (2009). ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-gamma production by mouse activated T lymphocytes. Immunol Lett. 122, 193-7.
8. Kadoshima-Yamaoka K, Goto M, Murakawa M, Yoshioka R, Tanaka Y, Inoue H, Murafuji H, Kanki S, Hayashi Y, Nagahira K, Ogata A, Nakatsuka T, Fukuda Y. (2009). ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-alpha level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate- induced skin inflammation model in mice. Eur J Pharmacol. in press.
10. Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Inoue H, Murafuji H, Hayashi Y, Miura K, Nakatsuka T, Nagahira K, Chamoto K, Fukuda Y, Nishimura T. (2009). Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells. Cell Immunol. in press.
Postdoctoral Fellow
Department of Anesthesia, Harvard Medical School
Immune Disease Institute
Education:
1996 B.S. Kyoto University
1998 M.S. Kyoto University
2001 Ph.D. Kyoto University
2009 Postdoc Immune Disease Institute & Harvard Medical School
Position & Employment:
1998-2001 Research Fellow (DC1), The Japanese Society for the Promotion of Science (JSPS)
2001-present Asubio Pharma Co., Limited, Researcher
2008- Research Fellow, CBR Institute for Biomedical Research, Harvard Medical School
Selected publications:
1. Lee KK, Murakawa M, Nishida E, Tsubuki S, kawashima S, Sakamaki K, Yonehara S (1998). Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis. Oncogene 16, 3029-3037.
2. Lee KK, Murakawa M, Takahashi S, Tsubuki S, Kawashima S, Sakamaki K, Yonehara S (1998). Purification, molecular cloning, and characterization of TRP32, a novel thioredoxin-related mammalian protein of 32 kDa. J Biol Chem. 273, 19160-6.
3. Murakawa M, Jung SK, Iijima K, Yonehara S. (2001). Apoptosis-inducing protein, AIP, from parasite-infected fish induces apoptosis in mammalian cells by two different molecular mechanisms. Cell Death Differ. 8, 298-307.
4. Murakawa M, Yamaoka K, Tanaka Y, Fukuda Y. (2006). Involvement of tumor necrosis factor (TNF)-alpha in phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin edema in mice. Biochem Pharmacol. 71, 1331-6
5. Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Nagahira K, Fukuda Y, Nishimura T. Murine NKT cells produce Th17 cytokine interleukin-22. (2009). Cell Immunol. 254, 81-4.
6. Kadoshima-Yamaoka K, Murakawa M, Goto M, Tanaka Y, Inoue H, Murafuji H, Hayashi Y, Nagahira K, Miura K, Nakatsuka T, Chamoto K, Fukuda Y, Nishimura T. (2009). Effect of phosphodiesterase 7 inhibitor ASB16165 on development and function of cytotoxic T lymphocyte. Int Immunopharmacol. 9, 97-102.
7. Kadoshima-Yamaoka K, Murakawa M, Goto M, Tanaka Y, Inoue H, Murafuji H, Nagahira A, Hayashi Y, Nagahira K, Miura K, Nakatsuka T, Chamoto K, Fukuda Y, Nishimura T. (2009). ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-gamma production by mouse activated T lymphocytes. Immunol Lett. 122, 193-7.
8. Kadoshima-Yamaoka K, Goto M, Murakawa M, Yoshioka R, Tanaka Y, Inoue H, Murafuji H, Kanki S, Hayashi Y, Nagahira K, Ogata A, Nakatsuka T, Fukuda Y. (2009). ASB16165, a phosphodiesterase 7A inhibitor, reduces cutaneous TNF-alpha level and ameliorates skin edema in phorbol ester 12-O-tetradecanoylphorbol-13-acetate- induced skin inflammation model in mice. Eur J Pharmacol. in press.
10. Goto M, Murakawa M, Kadoshima-Yamaoka K, Tanaka Y, Inoue H, Murafuji H, Hayashi Y, Miura K, Nakatsuka T, Nagahira K, Chamoto K, Fukuda Y, Nishimura T. (2009). Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells. Cell Immunol. in press.